Prophylaxis and treatment of acute graft-versus-host disease.
Journal Article (Review)
Acute graft-versus-host disease (GVHD) remains a major obstacle to successful allogeneic hematopoietic stem cell transplantation (HSCT). The ability to prevent GVHD--the application of successful prophylaxis--is crucial as treatment when prophylaxis fails or remains suboptimal. A calcineurin inhibitor in combination with methotrexate is still the mainstream regimen for prophylaxis of GVHD. Despite a steady increase in the repertoire of available drugs, corticosteroids remain the first-line therapy for patients who fail prevention and develop GVHD. Pan T-cell depletion studies suggest that success in prophylaxis and treatment of GVHD will depend on whether GVHD can be prevented without losing anti-malignancy and anti-infectious effects. Better understanding of the allogeneic response that is responsible for GVHD will facilitate the development of such an approach.
Full Text
Duke Authors
Cited Authors
- Chao, NJ; Chen, BJ
Published Date
- January 2006
Published In
Volume / Issue
- 43 / 1
Start / End Page
- 32 - 41
PubMed ID
- 16412787
Pubmed Central ID
- 16412787
International Standard Serial Number (ISSN)
- 0037-1963
Digital Object Identifier (DOI)
- 10.1053/j.seminhematol.2005.09.007
Language
- eng
Conference Location
- United States