Prophylaxis and treatment of acute graft-versus-host disease.

Journal Article (Review)

Acute graft-versus-host disease (GVHD) remains a major obstacle to successful allogeneic hematopoietic stem cell transplantation (HSCT). The ability to prevent GVHD--the application of successful prophylaxis--is crucial as treatment when prophylaxis fails or remains suboptimal. A calcineurin inhibitor in combination with methotrexate is still the mainstream regimen for prophylaxis of GVHD. Despite a steady increase in the repertoire of available drugs, corticosteroids remain the first-line therapy for patients who fail prevention and develop GVHD. Pan T-cell depletion studies suggest that success in prophylaxis and treatment of GVHD will depend on whether GVHD can be prevented without losing anti-malignancy and anti-infectious effects. Better understanding of the allogeneic response that is responsible for GVHD will facilitate the development of such an approach.

Full Text

Duke Authors

Cited Authors

  • Chao, NJ; Chen, BJ

Published Date

  • January 2006

Published In

Volume / Issue

  • 43 / 1

Start / End Page

  • 32 - 41

PubMed ID

  • 16412787

International Standard Serial Number (ISSN)

  • 0037-1963

Digital Object Identifier (DOI)

  • 10.1053/j.seminhematol.2005.09.007

Language

  • eng

Conference Location

  • United States