Single-dose extended-release epidural morphine for pain following hip arthroplasty.

Journal Article (Journal Article)

This open-label, serial-cohort pilot study evaluated DepoDur, a new, single-dose, extended-release epidural morphine (EREM) for pain control after hip arthroplasty. Single-dose EREM (10-30 mg) or a single dose of standard morphine sulfate (MS) (5 mg) was administered before surgery and spinal anesthesia. Among the 39 patients enrolled, total 48-hour supplemental fentanyl use was lower (P = 0.011 overall treatment) and median time to first postoperative fentanyl use was three- to six-fold longer (P < 0.001 overall treatment), among 10-, 20-, and 30-mg single-dose EREM patients versus MS patients. EREM patients reported higher levels of satisfaction with pain intensity scores comparable to MS patients. Safety results were similar between groups. Single-dose EREM was generally safe and effective for treating postoperative pain and reduced the need for supplemental analgesia.

Full Text

Duke Authors

Cited Authors

  • Viscusi, ER; Kopacz, D; Hartrick, C; Martin, G; Manvelian, G

Published Date

  • September 2006

Published In

Volume / Issue

  • 13 / 5

Start / End Page

  • 423 - 431

PubMed ID

  • 16988538

International Standard Serial Number (ISSN)

  • 1075-2765

Digital Object Identifier (DOI)

  • 10.1097/


  • eng

Conference Location

  • United States