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A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy.

Publication ,  Journal Article
Schmidt, S; Klaver, C; Saunders, A; Postel, E; De La Paz, M; Agarwal, A; Small, K; Udar, N; Ong, J; Chalukya, M; Nesburn, A; Kenney, C ...
Published in: Ophthalmic Genet
December 2002

Age-related maculopathy (ARM) is a multifactorial disorder known to have a substantial genetic component. The epsilon4 allele of the apolipoprotein E gene (APOE-4) has previously been reported to have a protective effect on ARM risk, while the APOE-2 allele may increase disease risk. This study combined four independent data sets (three US and one European) of Caucasian ARM patients and controls in order to obtain better statistical power to examine the role of APOE in ARM. APOE genotype and allele frequencies were compared for 617 ARM cases and 1260 controls, adjusting for age and sex differences between the two groups via multiple logistic regression. The protective effect of the APOE-4 allele on ARM risk was confirmed (age- and sex-adjusted odds ratio (OR) for APOE-4 carriers 0.54, 95% confidence interval (CI) 0.41-0.70, p < 0.0001). The effect of APOE-4 did not differ significantly between males and females and was observed consistently for both atrophic and neovascular ARM. Evidence for an increased risk of ARM due to the APOE-2 allele was found for men, but not for women (OR for men 1.54, 95% CI 0.97-2.45; OR for women 0.74, 95% CI 0.52-1.06, p = 0.01 for interaction of sex and APOE-2 carrier status). These data confirm that the APOE-4 allele, or an allele in linkage disequilibrium with it, reduces the risk of ARM. They also suggest that the effect of the APOE-2 allele may vary by gender, and that APOE-2 may confer an increased risk only to males.

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Published In

Ophthalmic Genet

DOI

ISSN

1381-6810

Publication Date

December 2002

Volume

23

Issue

4

Start / End Page

209 / 223

Location

England

Related Subject Headings

  • Risk Factors
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
  • Case-Control Studies
 

Citation

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ICMJE
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Schmidt, S., Klaver, C., Saunders, A., Postel, E., De La Paz, M., Agarwal, A., … Gorin, M. (2002). A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalmic Genet, 23(4), 209–223. https://doi.org/10.1076/opge.23.4.209.13883
Schmidt, Silke, Caroline Klaver, Ann Saunders, Eric Postel, Monica De La Paz, Anita Agarwal, Kent Small, et al. “A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy.Ophthalmic Genet 23, no. 4 (December 2002): 209–23. https://doi.org/10.1076/opge.23.4.209.13883.
Schmidt S, Klaver C, Saunders A, Postel E, De La Paz M, Agarwal A, et al. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalmic Genet. 2002 Dec;23(4):209–23.
Schmidt, Silke, et al. “A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy.Ophthalmic Genet, vol. 23, no. 4, Dec. 2002, pp. 209–23. Pubmed, doi:10.1076/opge.23.4.209.13883.
Schmidt S, Klaver C, Saunders A, Postel E, De La Paz M, Agarwal A, Small K, Udar N, Ong J, Chalukya M, Nesburn A, Kenney C, Domurath R, Hogan M, Mah T, Conley Y, Ferrell R, Weeks D, de Jong PTVM, van Duijn C, Haines J, Pericak-Vance M, Gorin M. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalmic Genet. 2002 Dec;23(4):209–223.
Journal cover image

Published In

Ophthalmic Genet

DOI

ISSN

1381-6810

Publication Date

December 2002

Volume

23

Issue

4

Start / End Page

209 / 223

Location

England

Related Subject Headings

  • Risk Factors
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Female
  • Case-Control Studies