Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis.

Published

Journal Article

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The contribution of the major histocompatibility complex (MHC) has been established in numerous genetic linkage and association studies. In addition to the MHC, the chromosome 19q13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS when family-based analyses were conducted. Furthermore, several clinical reports have suggested that the APOE-4 allele may be associated with more-severe disease and faster progression of disability. To thoroughly examine the role of APOE in MS, we genotyped its functional alleles, as well as seven single-nucleotide polymorphisms (SNPs) located primarily within 13 kb of APOE, in a data set of 398 families. Using family-based association analysis, we found statistically significant evidence that an SNP haplotype near APOE is associated with MS susceptibility (P=.005). An analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease (P=.03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02).

Full Text

Duke Authors

Cited Authors

  • Schmidt, S; Barcellos, LF; DeSombre, K; Rimmler, JB; Lincoln, RR; Bucher, P; Saunders, AM; Lai, E; Martin, ER; Vance, JM; Oksenberg, JR; Hauser, SL; Pericak-Vance, MA; Haines, JL; Multiple Sclerosis Genetics Group,

Published Date

  • March 2002

Published In

Volume / Issue

  • 70 / 3

Start / End Page

  • 708 - 717

PubMed ID

  • 11836653

Pubmed Central ID

  • 11836653

International Standard Serial Number (ISSN)

  • 0002-9297

Digital Object Identifier (DOI)

  • 10.1086/339269

Language

  • eng

Conference Location

  • United States