Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis.
Published
Journal Article
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The contribution of the major histocompatibility complex (MHC) has been established in numerous genetic linkage and association studies. In addition to the MHC, the chromosome 19q13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS when family-based analyses were conducted. Furthermore, several clinical reports have suggested that the APOE-4 allele may be associated with more-severe disease and faster progression of disability. To thoroughly examine the role of APOE in MS, we genotyped its functional alleles, as well as seven single-nucleotide polymorphisms (SNPs) located primarily within 13 kb of APOE, in a data set of 398 families. Using family-based association analysis, we found statistically significant evidence that an SNP haplotype near APOE is associated with MS susceptibility (P=.005). An analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease (P=.03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02).
Full Text
Duke Authors
Cited Authors
- Schmidt, S; Barcellos, LF; DeSombre, K; Rimmler, JB; Lincoln, RR; Bucher, P; Saunders, AM; Lai, E; Martin, ER; Vance, JM; Oksenberg, JR; Hauser, SL; Pericak-Vance, MA; Haines, JL; Multiple Sclerosis Genetics Group,
Published Date
- March 2002
Published In
Volume / Issue
- 70 / 3
Start / End Page
- 708 - 717
PubMed ID
- 11836653
Pubmed Central ID
- 11836653
International Standard Serial Number (ISSN)
- 0002-9297
Digital Object Identifier (DOI)
- 10.1086/339269
Language
- eng
Conference Location
- United States