Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.

Journal Article (Journal Article)

To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an angiogenic signature that included three angiogenin family members, one of which was found elevated in the plasma of men with prostate cancer. Thus, the MPAKT model may be useful in studying the role of Akt in prostate epithelial cell transformation and in the discovery of molecular markers relevant to human disease.

Full Text

Duke Authors

Cited Authors

  • Majumder, PK; Yeh, JJ; George, DJ; Febbo, PG; Kum, J; Xue, Q; Bikoff, R; Ma, H; Kantoff, PW; Golub, TR; Loda, M; Sellers, WR

Published Date

  • June 24, 2003

Published In

Volume / Issue

  • 100 / 13

Start / End Page

  • 7841 - 7846

PubMed ID

  • 12799464

Pubmed Central ID

  • PMC164675

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1232229100


  • eng

Conference Location

  • United States