Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.

Published

Journal Article

Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate cancer development remains enigmatic. Using a series of genetically defined immortalized and tumorigenic human prostate epithelial cells, we found that introduction of the androgen receptor induced differentiation of transformed prostate epithelial cells to a luminal phenotype reminiscent of organ-confined prostate cancer when placed in the prostate microenvironment. Moreover, androgen receptor expression converted previously androgen-independent, tumorigenic prostate epithelial cells into cells dependent on testosterone for tumor formation. These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium.

Full Text

Cited Authors

  • Berger, R; Febbo, PG; Majumder, PK; Zhao, JJ; Mukherjee, S; Signoretti, S; Campbell, KT; Sellers, WR; Roberts, TM; Loda, M; Golub, TR; Hahn, WC

Published Date

  • December 15, 2004

Published In

Volume / Issue

  • 64 / 24

Start / End Page

  • 8867 - 8875

PubMed ID

  • 15604246

Pubmed Central ID

  • 15604246

International Standard Serial Number (ISSN)

  • 0008-5472

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-04-2938

Language

  • eng

Conference Location

  • United States