Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

Published

Journal Article

Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta ARK inhibitor. Animals overexpressing beta ARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of beta-adrenergic receptors. Conversely, mice expressing the beta ARK inhibitor displayed enhanced cardiac contractility in vivo with or without isoproterenol. These animals demonstrate the important role of beta ARK in modulating in vivo myocardial function. Because increased amounts of beta ARK1 and diminished cardiac beta-adrenergic responsiveness characterize heart failure, these animals may provide experimental models to study the role of beta ARK in heart disease.

Full Text

Duke Authors

Cited Authors

  • Koch, WJ; Rockman, HA; Samama, P; Hamilton, RA; Bond, RA; Milano, CA; Lefkowitz, RJ

Published Date

  • June 1995

Published In

Volume / Issue

  • 268 / 5215

Start / End Page

  • 1350 - 1353

PubMed ID

  • 7761854

Pubmed Central ID

  • 7761854

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7761854

Language

  • eng