Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.

Published

Journal Article

Hormones and neurotransmitters may mediate common responses through receptors that couple to the same class of heterotrimeric guanine nucleotide-binding (G) protein. For example, several receptors that couple to Gq class proteins can induce cardiomyocyte hypertrophy. Class-specific inhibition of Gq-mediated signaling was produced in the hearts of transgenic mice by targeted expression of a carboxyl-terminal peptide of the alpha subunit Galphaq. When pressure overload was surgically induced, the transgenic mice developed significantly less ventricular hypertrophy than control animals. The data demonstrate the role of myocardial Gq in the initiation of myocardial hypertrophy and indicate a possible strategy for preventing pathophysiological signaling by simultaneously blocking multiple receptors coupled to Gq.

Full Text

Duke Authors

Cited Authors

  • Akhter, SA; Luttrell, LM; Rockman, HA; Iaccarino, G; Lefkowitz, RJ; Koch, WJ

Published Date

  • April 24, 1998

Published In

Volume / Issue

  • 280 / 5363

Start / End Page

  • 574 - 577

PubMed ID

  • 9554846

Pubmed Central ID

  • 9554846

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.280.5363.574

Language

  • eng

Conference Location

  • United States