Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.

Journal Article (Journal Article)

Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.

Full Text

Duke Authors

Cited Authors

  • VanDongen, AM; Codina, J; Olate, J; Mattera, R; Joho, R; Birnbaumer, L; Brown, AM

Published Date

  • December 9, 1988

Published In

Volume / Issue

  • 242 / 4884

Start / End Page

  • 1433 - 1437

PubMed ID

  • 3144040

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3144040

Language

  • eng

Conference Location

  • United States