A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Published
Journal Article
Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal.
Full Text
Duke Authors
Cited Authors
- Wood, MW; VanDongen, HM; VanDongen, AM
Published Date
- November 10, 1999
Published In
Volume / Issue
- 73 / 1-2
Start / End Page
- 189 - 192
PubMed ID
- 10581413
Pubmed Central ID
- 10581413
International Standard Serial Number (ISSN)
- 0169-328X
Digital Object Identifier (DOI)
- 10.1016/s0169-328x(99)00247-8
Language
- eng
Conference Location
- Netherlands