A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Publication
, Journal Article
Wood, MW; VanDongen, HM; VanDongen, AM
Published in: Brain Res Mol Brain Res
November 10, 1999
Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal.
Duke Scholars
Published In
Brain Res Mol Brain Res
DOI
ISSN
0169-328X
Publication Date
November 10, 1999
Volume
73
Issue
1-2
Start / End Page
189 / 192
Location
Netherlands
Related Subject Headings
- Xenopus laevis
- Receptors, N-Methyl-D-Aspartate
- Pyrrolidinones
- Oocytes
- Neurology & Neurosurgery
- Mutation
- Mice
- Kynurenic Acid
- Glycine
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Wood, M. W., VanDongen, H. M., & VanDongen, A. M. (1999). A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. Brain Res Mol Brain Res, 73(1–2), 189–192. https://doi.org/10.1016/s0169-328x(99)00247-8
Wood, M. W., H. M. VanDongen, and A. M. VanDongen. “A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.” Brain Res Mol Brain Res 73, no. 1–2 (November 10, 1999): 189–92. https://doi.org/10.1016/s0169-328x(99)00247-8.
Wood MW, VanDongen HM, VanDongen AM. A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. Brain Res Mol Brain Res. 1999 Nov 10;73(1–2):189–92.
Wood, M. W., et al. “A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.” Brain Res Mol Brain Res, vol. 73, no. 1–2, Nov. 1999, pp. 189–92. Pubmed, doi:10.1016/s0169-328x(99)00247-8.
Wood MW, VanDongen HM, VanDongen AM. A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. Brain Res Mol Brain Res. 1999 Nov 10;73(1–2):189–192.
Published In
Brain Res Mol Brain Res
DOI
ISSN
0169-328X
Publication Date
November 10, 1999
Volume
73
Issue
1-2
Start / End Page
189 / 192
Location
Netherlands
Related Subject Headings
- Xenopus laevis
- Receptors, N-Methyl-D-Aspartate
- Pyrrolidinones
- Oocytes
- Neurology & Neurosurgery
- Mutation
- Mice
- Kynurenic Acid
- Glycine
- Female