A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.

Journal Article (Journal Article)

Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal.

Full Text

Duke Authors

Cited Authors

  • Wood, MW; VanDongen, HM; VanDongen, AM

Published Date

  • November 10, 1999

Published In

Volume / Issue

  • 73 / 1-2

Start / End Page

  • 189 - 192

PubMed ID

  • 10581413

Pubmed Central ID

  • 10581413

International Standard Serial Number (ISSN)

  • 0169-328X

Digital Object Identifier (DOI)

  • 10.1016/s0169-328x(99)00247-8

Language

  • eng

Conference Location

  • Netherlands