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A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.

Publication ,  Journal Article
Wood, MW; VanDongen, HM; VanDongen, AM
Published in: Brain Res Mol Brain Res
November 10, 1999

Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partial agonist without altering its apparent affinity. The differential sensitivity of Ala714Leu to glycine agonists suggests that alanine 714 may be an intermediary in transducing the ligand binding signal.

Duke Scholars

Published In

Brain Res Mol Brain Res

DOI

ISSN

0169-328X

Publication Date

November 10, 1999

Volume

73

Issue

1-2

Start / End Page

189 / 192

Location

Netherlands

Related Subject Headings

  • Xenopus laevis
  • Receptors, N-Methyl-D-Aspartate
  • Pyrrolidinones
  • Oocytes
  • Neurology & Neurosurgery
  • Mutation
  • Mice
  • Kynurenic Acid
  • Glycine
  • Female
 

Citation

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Wood, M. W., VanDongen, H. M., & VanDongen, A. M. (1999). A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. Brain Res Mol Brain Res, 73(1–2), 189–192. https://doi.org/10.1016/s0169-328x(99)00247-8
Wood, M. W., H. M. VanDongen, and A. M. VanDongen. “A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.Brain Res Mol Brain Res 73, no. 1–2 (November 10, 1999): 189–92. https://doi.org/10.1016/s0169-328x(99)00247-8.
Wood MW, VanDongen HM, VanDongen AM. A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. Brain Res Mol Brain Res. 1999 Nov 10;73(1–2):189–92.
Wood, M. W., et al. “A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.Brain Res Mol Brain Res, vol. 73, no. 1–2, Nov. 1999, pp. 189–92. Pubmed, doi:10.1016/s0169-328x(99)00247-8.
Wood MW, VanDongen HM, VanDongen AM. A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. Brain Res Mol Brain Res. 1999 Nov 10;73(1–2):189–192.
Journal cover image

Published In

Brain Res Mol Brain Res

DOI

ISSN

0169-328X

Publication Date

November 10, 1999

Volume

73

Issue

1-2

Start / End Page

189 / 192

Location

Netherlands

Related Subject Headings

  • Xenopus laevis
  • Receptors, N-Methyl-D-Aspartate
  • Pyrrolidinones
  • Oocytes
  • Neurology & Neurosurgery
  • Mutation
  • Mice
  • Kynurenic Acid
  • Glycine
  • Female