Effects of mRNA untranslated regions on translational efficiency of NMDA receptor subunits.

Journal Article (Review)

Because NMDA receptors play critical roles in both neuronal survival and plasticity, their expression levels need to be carefully controlled. The number of functional NMDA receptors is temporally and spatially regulated at a hierarchy of levels, from gene transcription to protein trafficking. In this review we will focus on mechanisms for controlling functional expression of NMDA receptors that involve altering the efficacy of mRNA translation. One advantage of this level of control is that new receptors can be generated both rapidly and locally in response to appropriate synaptic activity patterns.

Full Text

Duke Authors

Cited Authors

  • VanDongen, AMJ; VanDongen, HMA

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 194 - 206

PubMed ID

  • 15148448

International Standard Serial Number (ISSN)

  • 1424-862X

Digital Object Identifier (DOI)

  • 10.1159/000077526

Language

  • eng

Conference Location

  • Switzerland