Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.

Published

Journal Article

Cerebellar granule cells are the most abundant type of neuron in the brain, but the molecular mechanisms that control their generation are incompletely understood. We show that Sonic hedgehog (Shh), which is made by Purkinje cells, regulates the division of granule cell precursors (GCPs). Treatment of GCPs with Shh prevents differentiation and induces a potent, long-lasting proliferative response. This response can be inhibited by basic fibroblast growth factor or by activation of protein kinase A. Blocking Shh function in vivo dramatically reduces GCP proliferation. These findings provide insight into the mechanisms of normal growth and tumorigenesis in the cerebellum.

Full Text

Cited Authors

  • Wechsler-Reya, RJ; Scott, MP

Published Date

  • January 1999

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 103 - 114

PubMed ID

  • 10027293

Pubmed Central ID

  • 10027293

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(00)80682-0

Language

  • eng