Caught in the matrix: how vitronectin controls neuronal differentiation.


Journal Article (Review)

Cerebellar granule cells are the most abundant neurons in the brain and are crucial to the circuitry that controls motor coordination. The proliferation of granule cell precursors (GCPs) is controlled by the secreted signaling molecule Sonic hedgehog (Shh), but the factors that regulate GCP differentiation remain a mystery. A recent study suggests that the extracellular matrix protein vitronectin might tell GCPs when to stop dividing and begin differentiation.

Full Text

Cited Authors

  • Wechsler-Reya, RJ

Published Date

  • December 2001

Published In

Volume / Issue

  • 24 / 12

Start / End Page

  • 680 - 682

PubMed ID

  • 11718852

Pubmed Central ID

  • 11718852

Electronic International Standard Serial Number (EISSN)

  • 1878-108X

International Standard Serial Number (ISSN)

  • 0166-2236

Digital Object Identifier (DOI)

  • 10.1016/s0166-2236(00)02058-0


  • eng