Getting at the root and stem of brain tumors.


Journal Article (Review)

Brain tumors are among the most aggressive and intractable types of cancer. Recent studies indicate that brain tumor cells resemble neural stem cells in terms of phenotype, signaling, and behavior in vitro. In light of these similarities, it has been suggested that brain tumors arise from stem cells, that they co-opt stem cell strategies for self-renewal, and even that they contain "cancer stem cells" that are critical for tumor maintenance. We will examine these possibilities and discuss their implications for the understanding and treatment of brain tumors.

Full Text

Cited Authors

  • Oliver, TG; Wechsler-Reya, RJ

Published Date

  • June 2004

Published In

Volume / Issue

  • 42 / 6

Start / End Page

  • 885 - 888

PubMed ID

  • 15207233

Pubmed Central ID

  • 15207233

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2004.06.011


  • eng