Morphing into cancer: the role of developmental signaling pathways in brain tumor formation.


Journal Article (Review)

Morphogens play a critical role in most aspects of development, including expansion and patterning of the central nervous system. Activating germline mutations in components of the Hedgehog and Wnt pathways have provided evidence for the important roles morphogens play in the genesis of brain tumors such as cerebellar medulloblastoma. In addition, aberrant expression of transforming growth factor-beta (TGF-beta) superfamily members has been demonstrated to contribute to progression of malignant gliomas. This review summarizes our current knowledge about the roles of morphogens in central nervous system tumorigenesis.

Full Text

Cited Authors

  • Fogarty, MP; Kessler, JD; Wechsler-Reya, RJ

Published Date

  • September 2005

Published In

Volume / Issue

  • 64 / 4

Start / End Page

  • 458 - 475

PubMed ID

  • 16041741

Pubmed Central ID

  • 16041741

Electronic International Standard Serial Number (EISSN)

  • 1097-4695

International Standard Serial Number (ISSN)

  • 0022-3034

Digital Object Identifier (DOI)

  • 10.1002/neu.20166


  • eng