The neurobiology of neurooncology.


Journal Article (Review)

The histological classification of brain tumors currently is based on the morphological appearance and protein expression patterns that reflect specific cell types within the central nervous system. Recent studies have suggested that the cells of origin for brain tumors may persist in the fully formed tumors, and that these "cancer stem cells" might represent the relevant cellular targets for anticancer therapy. In this regard, insights into the developmental neurobiology of brain tumors has significant impact on our understanding of the molecular and cellular pathogenesis of these devastating cancers, as well as the development of new strategies for treating brain tumors.

Full Text

Cited Authors

  • Read, T-A; Hegedus, B; Wechsler-Reya, R; Gutmann, DH

Published Date

  • July 2006

Published In

Volume / Issue

  • 60 / 1

Start / End Page

  • 3 - 11

PubMed ID

  • 16802285

Pubmed Central ID

  • 16802285

Electronic International Standard Serial Number (EISSN)

  • 1531-8249

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.20912


  • eng