Alterations in receptors for sensory neuropeptides in human inflammatory bowel disease.


Journal Article

Glutamate and several neuropeptides are synthesized and released by subpopulations of primary afferent neurons. These sensory neurons play a role in regulating the inflammatory and immune responses in peripheral tissues. We have explored what changes occur in the location and concentration of receptor binding sites for sensory neurotransmitters in two human inflammatory diseases, ulcerative colitis and Crohn's disease, using quantitative receptor autoradiography. The sensory neurotransmitter receptors included bombesin, calcitonin gene-related peptide-alpha, cholecystokinin, galanin, glutamate, somatostatin, neurokinin A (substance K), substance P, and vasoactive intestinal polypeptide. Of the nine receptor binding sites examined only binding sites for substance P and vasoactive intestinal peptide were significantly altered in the inflamed tissue. These data suggest that substance P is involved in regulating the inflammatory and immune responses in human inflammatory diseases and indicate a specificity of efferent action for each sensory neurotransmitter in peripheral tissues.

Full Text

Duke Authors

Cited Authors

  • Mantyh, PW; Catton, M; Maggio, JE; Vigna, SR

Published Date

  • 1991

Published In

Volume / Issue

  • 298 /

Start / End Page

  • 253 - 283

PubMed ID

  • 1659149

Pubmed Central ID

  • 1659149

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-1-4899-0744-8_24


  • eng

Conference Location

  • United States