The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats.


Journal Article

The mechanism by which Clostridium difficile toxin A causes substance P (SP) release and subsequent inflammation in the rat ileum is unknown. Pretreatment with the vanilloid receptor subtype 1 (VR1) antagonist, capsazepine, before toxin A administration significantly inhibited toxin A-induced SP release and intestinal inflammation. Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation. These results suggest that intraluminal toxin A causes SP release from primary sensory neurons via stimulation of VR1 receptors resulting in intestinal inflammation.

Full Text

Duke Authors

Cited Authors

  • McVey, DC; Vigna, SR

Published Date

  • September 2001

Published In

Volume / Issue

  • 22 / 9

Start / End Page

  • 1439 - 1446

PubMed ID

  • 11514026

Pubmed Central ID

  • 11514026

International Standard Serial Number (ISSN)

  • 0196-9781

Digital Object Identifier (DOI)

  • 10.1016/s0196-9781(01)00463-6


  • eng

Conference Location

  • United States