Monitor peptide binding sites are expressed in the rat liver and small intestine.

Published

Journal Article

125I-monitor peptide binding was performed using frozen sections of the rat liver and gut and visualized using autoradiography. Saturable binding was observed in unidentified single cells in the liver and in the mucosa of the small intestine. Epidermal growth factor (EGF) and GTPgammaS did not inhibit 125I-monitor peptide binding indicating that the binding sites are not EGF receptors or G protein-coupled receptors. The liver binding site exhibited an affinity 3.7-4.4-fold higher than those in the small intestine. It has been established that intraluminal monitor peptide releases cholecystokinin from the small intestine. The present results indicate that monitor peptide may also have liver associated functions.

Full Text

Duke Authors

Cited Authors

  • McVey, DC; Romac, JM; Clay, WC; Kost, TA; Liddle, RA; Vigna, SR

Published Date

  • 1999

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 457 - 464

PubMed ID

  • 10458515

Pubmed Central ID

  • 10458515

International Standard Serial Number (ISSN)

  • 0196-9781

Language

  • eng

Conference Location

  • United States