Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.

Published

Journal Article

In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in the spinal cord and stimulated endocytosis of substance P receptors in rat spinal cord neurons. The distal dendrites that showed substance P receptor internalization underwent morphological reorganization, changing from a tubular structure to one characterized by swollen varicosities connected by thin segments. This internalization and dendritic structural reorganization provided a specific image of neurons activated by substance P. Thus receptor internalization can drive reversible structural changes in central nervous system neurons in vivo. Both of these processes may be involved in neuronal plasticity.

Full Text

Duke Authors

Cited Authors

  • Mantyh, PW; DeMaster, E; Malhotra, A; Ghilardi, JR; Rogers, SD; Mantyh, CR; Liu, H; Basbaum, AI; Vigna, SR; Maggio, JE

Published Date

  • June 1995

Published In

Volume / Issue

  • 268 / 5217

Start / End Page

  • 1629 - 1632

PubMed ID

  • 7539937

Pubmed Central ID

  • 7539937

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7539937

Language

  • eng