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Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.

Publication ,  Journal Article
Mantyh, CR; Vigna, SR; Maggio, JE; Mantyh, PW; Bollinger, RR; Pappas, TN
Published in: Neurosci Lett
September 12, 1994

Previous reports have described the ectopic expression of substance P binding sites on lymphoid aggregates and small blood vessels in inflammatory bowel disease. In this report, three non-peptide NK-1 receptor antagonists, CP-96,345, RP-67,580, and L-703,606 abolished saturable 125I-Bolton-Hunter substance P binding to the ectopically expressed receptors in frozen sections of surgically resected bowel from five patients with either Crohn's disease or ulcerative colitis. The rank order of affinity was approximately substance P approximately CP-96,345 approximately L-703,606 > RP-67,580. These results suggest that: (i) the ectopically expressed substance P binding sites in inflammatory bowel disease are authentic NK-1 receptors, (ii) all ectopically expressed receptors on small blood vessels, and lymphoid aggregates as well as normally expressed receptors on the bowel circular muscle have similar receptor affinities and specificities for substance P and the non-peptide antagonists, and (iii) non-peptide antagonists may be therapeutically beneficial in inflammatory bowel disease by inhibiting the pro-inflammatory effects of substance P acting via the NK-1 receptor.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

September 12, 1994

Volume

178

Issue

2

Start / End Page

255 / 259

Location

Ireland

Related Subject Headings

  • Substance P
  • Receptors, Neurokinin-1
  • Quinuclidines
  • Neurokinin-1 Receptor Antagonists
  • Lymphoid Tissue
  • Isoindoles
  • Intestines
  • Intestinal Mucosa
  • Inflammatory Bowel Diseases
  • Indoles
 

Citation

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Mantyh, C. R., Vigna, S. R., Maggio, J. E., Mantyh, P. W., Bollinger, R. R., & Pappas, T. N. (1994). Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neurosci Lett, 178(2), 255–259. https://doi.org/10.1016/0304-3940(94)90772-2
Mantyh, C. R., S. R. Vigna, J. E. Maggio, P. W. Mantyh, R. R. Bollinger, and T. N. Pappas. “Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.Neurosci Lett 178, no. 2 (September 12, 1994): 255–59. https://doi.org/10.1016/0304-3940(94)90772-2.
Mantyh CR, Vigna SR, Maggio JE, Mantyh PW, Bollinger RR, Pappas TN. Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neurosci Lett. 1994 Sep 12;178(2):255–9.
Mantyh, C. R., et al. “Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.Neurosci Lett, vol. 178, no. 2, Sept. 1994, pp. 255–59. Pubmed, doi:10.1016/0304-3940(94)90772-2.
Mantyh CR, Vigna SR, Maggio JE, Mantyh PW, Bollinger RR, Pappas TN. Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. Neurosci Lett. 1994 Sep 12;178(2):255–259.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

September 12, 1994

Volume

178

Issue

2

Start / End Page

255 / 259

Location

Ireland

Related Subject Headings

  • Substance P
  • Receptors, Neurokinin-1
  • Quinuclidines
  • Neurokinin-1 Receptor Antagonists
  • Lymphoid Tissue
  • Isoindoles
  • Intestines
  • Intestinal Mucosa
  • Inflammatory Bowel Diseases
  • Indoles