Vasoactive intestinal peptide (VIP) receptors in the canine gastrointestinal tract.

Journal Article (Journal Article)

Vasoactive intestinal peptide (VIP) is a putative neurotransmitter in both the brain and peripheral tissues. To define possible target tissues of VIP we have used quantitative receptor autoradiography to localize and quantify the distribution of 125I-VIP receptor binding sites in the canine gastrointestinal tract. While the distribution of VIP binding sites was different for each segment examined, specific VIP binding sites were localized to the mucosa, the muscularis mucosa, the smooth muscle of submucosal arterioles, lymph nodules, and the circular and longitudinal smooth muscle of the muscularis externa. These results identify putative target tissues of VIP action in the canine gastrointestinal tract. In correlation with physiological data, VIP sites appear to be involved in the regulation of a variety of gastrointestinal functions including epithelial ion transport, gastric secretion, hemodynamic regulation, immune response, esophageal, gastric and intestinal motility.

Full Text

Duke Authors

Cited Authors

  • Zimmerman, RP; Gates, TS; Mantyh, CR; Vigna, SR; Boehmer, CG; Mantyh, PW

Published Date

  • 1988

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 1241 - 1253

PubMed ID

  • 2854625

International Standard Serial Number (ISSN)

  • 0196-9781

Digital Object Identifier (DOI)

  • 10.1016/0196-9781(88)90188-x


  • eng

Conference Location

  • United States