Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.

Journal Article

The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (alpha) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (beta) or a crossreactive determinant(s) on the HLA-DR3 alpha subunit and an additional alpha subunit. MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.

Full Text

Duke Authors

Cited Authors

  • Markert, ML; Cresswell, P

Published Date

  • October 1, 1980

Published In

Volume / Issue

  • 77 / 10

Start / End Page

  • 6101 - 6104

PubMed ID

  • 6160591

International Standard Serial Number (ISSN)

  • 0027-8424

Language

  • eng

Conference Location

  • United States