Human B cell alloantigens; alpha subunit variability.

Journal Article (Journal Article)

Human B cell alloantigens were studied by two-dimensional gel electrophoresis. The heavy (alpha) and light (beta) chains precipitated by xenoantisera were compared on B lymphoblastoid cell lines of different HLA-DR types. In accordance with the results of other investigators, we observed considerable electrophoretic variability of beta subunits. Significant electrophoretic differences between alpha subunits isolated from different cells were also observed through the use of a pH 5 to 7 gradient in the isoelectric focusing dimension. HLA-DR allelic products from a heterozygous line exhibited differences in beta subunit electrophoretic mobility but apparent identity of alpha subunits.

Full Text

Duke Authors

Cited Authors

  • Markert, ML; Cresswell, P

Published Date

  • May 1, 1982

Published In

Volume / Issue

  • 128 / 5

Start / End Page

  • 1999 - 2003

PubMed ID

  • 6977579

International Standard Serial Number (ISSN)

  • 0022-1767


  • eng

Conference Location

  • United States