Newer treatments for HIV in children.

Published

Journal Article (Review)

PURPOSE OF REVIEW: Several new antiretroviral agents have been introduced into pediatric and adult use. This review will summarize information about these new agents and other recent advances in the care of HIV-infected children. RECENT FINDINGS: New drugs like tenofovir, emtricitabine, and enfuvirtide are being rapidly introduced into antiretroviral treatments for adult patients. In addition, some well-established drugs are being modified to make them more convenient (specifically didanosine and stavudine). Unfortunately, pediatric data lag for these new agents, in some cases because of complicated pharmacokinetics in children. At the same time, critical information on how to use established drugs like nelfinavir and efavirenz in younger children is slowly becoming available. Although antiretroviral treatment in children has often been initiated at standard doses of milligrams per kilogram, and susceptibility to drug was presumed in individuals without a previous history of exposure, recent data show that some primary infections are caused by drug-resistant virus, and there is a tremendous variability in serum drug levels in children. Researchers and clinicians should consider the role of baseline antiretroviral susceptibility testing and therapeutic drug monitoring to identify the optimal treatment for each child. SUMMARY: New therapeutic options for children with HIV infection are becoming available as the pharmacokinetics and best strategies for use of newer drugs are studied.

Full Text

Duke Authors

Cited Authors

  • McKinney, RE; Cunningham, CK

Published Date

  • February 2004

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 76 - 79

PubMed ID

  • 14758118

Pubmed Central ID

  • 14758118

International Standard Serial Number (ISSN)

  • 1040-8703

Digital Object Identifier (DOI)

  • 10.1097/00008480-200402000-00014

Language

  • eng

Conference Location

  • United States