Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine.


Journal Article

Infants born to human immunodeficiency virus type 1 (HIV-1)-infected mothers were immunized at birth and at ages 4, 12, and 20 weeks with low-, medium-, or high-dose recombinant gp120 vaccine with MF59 adjuvant (HIV-1(SF-2); n=52) or with MF59 alone as a placebo (n=9). An accelerated schedule (birth and ages 2, 8, and 20 weeks) was used for an additional 10 infants receiving the defined optimal dose and for 3 infants receiving placebo. At 24 weeks, anti-gp120 ELISA titers were greater for vaccine-immunized than for placebo-immunized infants on both schedules, and 87% of vaccinees had a vaccine-induced antibody response. At 12 weeks, antibody titers of infants on the accelerated vaccine schedule exceeded those of infants receiving placebo (4949 vs. 551; P=.01), and 63% of the vaccinees met the response criteria. Thus, an accelerated schedule of gp120 vaccinations generated an antibody response to HIV-1 envelope distinct from transplacental maternal antibody by age 12 weeks. These results provide support for further studies of vaccine strategies to prevent mother-to-infant HIV-1 transmission.

Full Text

Duke Authors

Cited Authors

  • McFarland, EJ; Borkowsky, W; Fenton, T; Wara, D; McNamara, J; Samson, P; Kang, M; Mofenson, L; Cunningham, C; Duliege, AM; Sinangil, F; Spector, SA; Jimenez, E; Bryson, Y; Burchett, S; Frenkel, LM; Yogev, R; Gigliotti, F; Luzuriaga, K; Livingston, RA; AIDS Clinical Trials Group 230 Collaborators,

Published Date

  • November 15, 2001

Published In

Volume / Issue

  • 184 / 10

Start / End Page

  • 1331 - 1335

PubMed ID

  • 11679925

Pubmed Central ID

  • 11679925

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/323994


  • eng

Conference Location

  • United States