Absence of human herpes virus 8 DNA sequences in large granular lymphocyte (LGL) leukemia.


Journal Article

The etiology of large granular lymphocyte (LGL) leukemia is uncertain. Recently, a Kaposi's sarcoma-associated herpes virus, denoted as human herpes virus 8 (HHV-8), has been identified. Some data suggest that HHV-8 and Epstein-Barr virus (EBV) may interact to induce malignant transformation. Infection with EBV has been implicated in the pathogenesis of some cases of LGL leukemia. Therefore, we performed PCR analyses for HHV-8 detection in samples from nineteen patients with LGL leukemia; three of these samples contained the EBV genome. We could not detect HHV-8 sequences in any of these patients. Therefore, HHV-8 infection is not involved in the pathogenesis of T-LGL leukemia.

Full Text

Duke Authors

Cited Authors

  • Loughran, TP; Abbott, L; Gentile, TC; Love, J; Cunningham, C; Friedman-Kien, A; Huang, YQ; Poiesz, BJ

Published Date

  • June 1997

Published In

Volume / Issue

  • 26 / 1-2

Start / End Page

  • 177 - 180

PubMed ID

  • 9250803

Pubmed Central ID

  • 9250803

International Standard Serial Number (ISSN)

  • 1042-8194

Digital Object Identifier (DOI)

  • 10.3109/10428199709109173


  • eng

Conference Location

  • United States