A cell-based model of coagulation and the role of factor VIIa.

Published

Journal Article (Review)

Our cell-based model of haemostasis replaces the traditional 'cascade' hypothesis, and proposes that coagulation takes place on different cell surfaces in three overlapping steps: initiation, amplification, and propagation. In highlighting the importance of cellular control during coagulation, the cell-based model allows a more thorough understanding of how haemostasis works in vivo, and sheds light on the pathophysiological mechanisms behind certain coagulation disorders. For instance, this model proposes that haemophilia involves a failure of platelet-surface FXa generation, leading to a lack of platelet-surface thrombin production. Our data suggest that high-dose FVIIa is able to bind weakly to activated platelets, independently of tissue factor, in order to generate sufficient amounts of FXa to support a burst bf thrombin generation in the absence of FIXa/FVIIIa. The considerable success of high-dose recombinant FVIIa (rFVIIa; NovoSeven, Novo Nordisk, Copenhagen, Denmark) as a therapy for patients with haemophilia and inhibitors has led to its use in a growing number of alternative indications. We believe that even in the presence of the FIXa/FVIIIa complex, rFVIIa may be able to enhance both FXa and FIXa levels on the surface of activated platelets, thus increasing the production of thrombin.

Full Text

Duke Authors

Cited Authors

  • Hoffman, M

Published Date

  • September 2003

Published In

Volume / Issue

  • 17 Suppl 1 /

Start / End Page

  • S1 - S5

PubMed ID

  • 14697207

Pubmed Central ID

  • 14697207

Electronic International Standard Serial Number (EISSN)

  • 1532-1681

International Standard Serial Number (ISSN)

  • 0268-960X

Digital Object Identifier (DOI)

  • 10.1016/s0268-960x(03)90000-2

Language

  • eng