Newer concepts of blood coagulation.

Journal Article (Journal Article)

In this report we describe an in vitro model of blood coagulation reactions that mimics as closely as possible the in vivo condition. Our model indicates that the tissue factor-factor VIIa complex initiates coagulation by activating small amounts of both factor IX and factor X in the environment of the tissue factor bearing cell. Factor Xa and factor IXa formed in the initial reaction then play very distinct roles in the subsequent interactions of the clotting mechanism leading to a burst of thrombin generation on the platelet surface. Our results also indicate that factor XI can be activated by thrombin in the absence of factor XII and that the function of factor XI is simply to enhance conversion of factor IX to factor IXa resulting in enhanced thrombin generation on the platelet surface.

Full Text

Duke Authors

Cited Authors

  • Roberts, HR; Monroe, DM; Oliver, JA; Chang, JY; Hoffman, M

Published Date

  • July 1998

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 331 - 334

PubMed ID

  • 9873750

International Standard Serial Number (ISSN)

  • 1351-8216

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2516.1998.440331.x


  • eng

Conference Location

  • England