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Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.

Publication ,  Journal Article
Hoffman, M
Published in: Vox Sang
1991

The transfusion of incompatible red blood cells (RBC) rapidly results in the development of fever by an unknown mechanism. In this study, the human monocyte secretion of the endogenous pyrogens tumor necrosis factor (TNF) and interleukin-1 (IL-1) was measured. Exposure to human RBC sensitized with antibodies to D or Fya antigens induced the rapid secretion of TNF, but not IL-1. TNF secretion persisted when monocytes remained in contact with sensitized RBC, but returned to baseline several hours after removal of RBC. Thus, TNF secreted by monocytes may be a mediator of fever during the immune-mediated destruction of RBC in vivo.

Duke Scholars

Published In

Vox Sang

DOI

ISSN

0042-9007

Publication Date

1991

Volume

60

Issue

3

Start / End Page

184 / 187

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transfusion Reaction
  • Monocytes
  • Isoantibodies
  • Interleukin-1
  • Humans
  • Fever
  • Erythrocytes
  • Cardiovascular System & Hematology
  • Blood Group Incompatibility
 
Journal cover image

Published In

Vox Sang

DOI

ISSN

0042-9007

Publication Date

1991

Volume

60

Issue

3

Start / End Page

184 / 187

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transfusion Reaction
  • Monocytes
  • Isoantibodies
  • Interleukin-1
  • Humans
  • Fever
  • Erythrocytes
  • Cardiovascular System & Hematology
  • Blood Group Incompatibility