Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.

Journal Article (Journal Article)

The transfusion of incompatible red blood cells (RBC) rapidly results in the development of fever by an unknown mechanism. In this study, the human monocyte secretion of the endogenous pyrogens tumor necrosis factor (TNF) and interleukin-1 (IL-1) was measured. Exposure to human RBC sensitized with antibodies to D or Fya antigens induced the rapid secretion of TNF, but not IL-1. TNF secretion persisted when monocytes remained in contact with sensitized RBC, but returned to baseline several hours after removal of RBC. Thus, TNF secreted by monocytes may be a mediator of fever during the immune-mediated destruction of RBC in vivo.

Full Text

Duke Authors

Cited Authors

  • Hoffman, M

Published Date

  • 1991

Published In

Volume / Issue

  • 60 / 3

Start / End Page

  • 184 - 187

PubMed ID

  • 1862642

International Standard Serial Number (ISSN)

  • 0042-9007

Digital Object Identifier (DOI)

  • 10.1111/j.1423-0410.1991.tb00900.x


  • eng

Conference Location

  • England