Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.
Journal Article (Journal Article)
The transfusion of incompatible red blood cells (RBC) rapidly results in the development of fever by an unknown mechanism. In this study, the human monocyte secretion of the endogenous pyrogens tumor necrosis factor (TNF) and interleukin-1 (IL-1) was measured. Exposure to human RBC sensitized with antibodies to D or Fya antigens induced the rapid secretion of TNF, but not IL-1. TNF secretion persisted when monocytes remained in contact with sensitized RBC, but returned to baseline several hours after removal of RBC. Thus, TNF secreted by monocytes may be a mediator of fever during the immune-mediated destruction of RBC in vivo.
Full Text
Duke Authors
Cited Authors
- Hoffman, M
Published Date
- 1991
Published In
Volume / Issue
- 60 / 3
Start / End Page
- 184 - 187
PubMed ID
- 1862642
International Standard Serial Number (ISSN)
- 0042-9007
Digital Object Identifier (DOI)
- 10.1111/j.1423-0410.1991.tb00900.x
Language
- eng
Conference Location
- England