Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.
Publication
, Journal Article
Hoffman, M
Published in: Vox Sang
1991
The transfusion of incompatible red blood cells (RBC) rapidly results in the development of fever by an unknown mechanism. In this study, the human monocyte secretion of the endogenous pyrogens tumor necrosis factor (TNF) and interleukin-1 (IL-1) was measured. Exposure to human RBC sensitized with antibodies to D or Fya antigens induced the rapid secretion of TNF, but not IL-1. TNF secretion persisted when monocytes remained in contact with sensitized RBC, but returned to baseline several hours after removal of RBC. Thus, TNF secreted by monocytes may be a mediator of fever during the immune-mediated destruction of RBC in vivo.
Duke Scholars
Published In
Vox Sang
DOI
ISSN
0042-9007
Publication Date
1991
Volume
60
Issue
3
Start / End Page
184 / 187
Location
England
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Transfusion Reaction
- Monocytes
- Isoantibodies
- Interleukin-1
- Humans
- Fever
- Erythrocytes
- Cardiovascular System & Hematology
- Blood Group Incompatibility
Citation
APA
Chicago
ICMJE
MLA
NLM
Hoffman, M. (1991). Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions. Vox Sang, 60(3), 184–187. https://doi.org/10.1111/j.1423-0410.1991.tb00900.x
Hoffman, M. “Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.” Vox Sang 60, no. 3 (1991): 184–87. https://doi.org/10.1111/j.1423-0410.1991.tb00900.x.
Hoffman, M. “Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions.” Vox Sang, vol. 60, no. 3, 1991, pp. 184–87. Pubmed, doi:10.1111/j.1423-0410.1991.tb00900.x.
Hoffman M. Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions. Vox Sang. 1991;60(3):184–187.
Published In
Vox Sang
DOI
ISSN
0042-9007
Publication Date
1991
Volume
60
Issue
3
Start / End Page
184 / 187
Location
England
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Transfusion Reaction
- Monocytes
- Isoantibodies
- Interleukin-1
- Humans
- Fever
- Erythrocytes
- Cardiovascular System & Hematology
- Blood Group Incompatibility