Cellular interactions in hemostasis.
Publication
, Journal Article
Hoffman, M; Monroe, DM; Roberts, HR
Published in: Haemostasis
1996
Coagulation reactions normally occur on cell membranes in vivo. Using a cell-based in vitro model system, we have shown that where a factor is located, not simply how much is activated, is critically important in determining its role in hemostasis. Factor Xa activated on a tissue factor (TF)-bearing cell is not equivalent to factor Xa activated on a platelet surface. Factor IX and factor VIII are required for hemostasis because they combine to generate factor Xa on the platelet surface. Factor X activation by factor VIIa/TF does not compensate for a lack of factor IX or VIII because the factor Xa activated by VIIa/TF is located on the wrong surface for efficient thrombin generation.
Duke Scholars
Published In
Haemostasis
DOI
ISSN
0301-0147
Publication Date
1996
Volume
26 Suppl 1
Start / End Page
12 / 16
Location
Switzerland
Related Subject Headings
- Thromboplastin
- Models, Biological
- In Vitro Techniques
- Humans
- Hemostasis
- Factor VIII
- Factor IX
- Cell Communication
- Cardiovascular System & Hematology
- Blood Coagulation
Citation
APA
Chicago
ICMJE
MLA
NLM
Hoffman, M., Monroe, D. M., & Roberts, H. R. (1996). Cellular interactions in hemostasis. Haemostasis, 26 Suppl 1, 12–16. https://doi.org/10.1159/000217233
Hoffman, M., D. M. Monroe, and H. R. Roberts. “Cellular interactions in hemostasis.” Haemostasis 26 Suppl 1 (1996): 12–16. https://doi.org/10.1159/000217233.
Hoffman M, Monroe DM, Roberts HR. Cellular interactions in hemostasis. Haemostasis. 1996;26 Suppl 1:12–6.
Hoffman, M., et al. “Cellular interactions in hemostasis.” Haemostasis, vol. 26 Suppl 1, 1996, pp. 12–16. Pubmed, doi:10.1159/000217233.
Hoffman M, Monroe DM, Roberts HR. Cellular interactions in hemostasis. Haemostasis. 1996;26 Suppl 1:12–16.
Published In
Haemostasis
DOI
ISSN
0301-0147
Publication Date
1996
Volume
26 Suppl 1
Start / End Page
12 / 16
Location
Switzerland
Related Subject Headings
- Thromboplastin
- Models, Biological
- In Vitro Techniques
- Humans
- Hemostasis
- Factor VIII
- Factor IX
- Cell Communication
- Cardiovascular System & Hematology
- Blood Coagulation