Cellular interactions in hemostasis.

Journal Article (Journal Article;Review)

Coagulation reactions normally occur on cell membranes in vivo. Using a cell-based in vitro model system, we have shown that where a factor is located, not simply how much is activated, is critically important in determining its role in hemostasis. Factor Xa activated on a tissue factor (TF)-bearing cell is not equivalent to factor Xa activated on a platelet surface. Factor IX and factor VIII are required for hemostasis because they combine to generate factor Xa on the platelet surface. Factor X activation by factor VIIa/TF does not compensate for a lack of factor IX or VIII because the factor Xa activated by VIIa/TF is located on the wrong surface for efficient thrombin generation.

Full Text

Duke Authors

Cited Authors

  • Hoffman, M; Monroe, DM; Roberts, HR

Published Date

  • 1996

Published In

Volume / Issue

  • 26 Suppl 1 /

Start / End Page

  • 12 - 16

PubMed ID

  • 8904166

International Standard Serial Number (ISSN)

  • 0301-0147

Digital Object Identifier (DOI)

  • 10.1159/000217233


  • eng

Conference Location

  • Switzerland