Cellular interactions in hemostasis.
Journal Article (Journal Article;Review)
Coagulation reactions normally occur on cell membranes in vivo. Using a cell-based in vitro model system, we have shown that where a factor is located, not simply how much is activated, is critically important in determining its role in hemostasis. Factor Xa activated on a tissue factor (TF)-bearing cell is not equivalent to factor Xa activated on a platelet surface. Factor IX and factor VIII are required for hemostasis because they combine to generate factor Xa on the platelet surface. Factor X activation by factor VIIa/TF does not compensate for a lack of factor IX or VIII because the factor Xa activated by VIIa/TF is located on the wrong surface for efficient thrombin generation.
Full Text
Duke Authors
Cited Authors
- Hoffman, M; Monroe, DM; Roberts, HR
Published Date
- 1996
Published In
Volume / Issue
- 26 Suppl 1 /
Start / End Page
- 12 - 16
PubMed ID
- 8904166
International Standard Serial Number (ISSN)
- 0301-0147
Digital Object Identifier (DOI)
- 10.1159/000217233
Language
- eng
Conference Location
- Switzerland