Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.
Publication
, Journal Article
Pizzo, SV; Murray, JC; Gonias, SL
Published in: Arch Pathol Lab Med
June 1986
Atrophie blanche is a skin disorder characterized by recurrent ulceration and fibrosis. It is one of a group of cutaneous vasculitides associated with decreased blood fibrinolytic activity. We examined pre- and post-venous occlusion plasma from eight patients with atrophie blanche for release of vascular (tissue-type) plasminogen activator (t-PA). The average plasma level of releasable t-PA was only 0.03 IU/mL, compared with 0.70 IU/mL for 118 healthy controls. Therefore, the fibrinolytic disorder in atrophie blanche is associated with defective release of t-PA from blood vessel walls.
Duke Scholars
Published In
Arch Pathol Lab Med
ISSN
0003-9985
Publication Date
June 1986
Volume
110
Issue
6
Start / End Page
517 / 519
Location
United States
Related Subject Headings
- Vasculitis
- Tissue Plasminogen Activator
- Skin Diseases
- Skin
- Pathology
- Male
- Humans
- Fibrinolysis
- Female
- Atrophy
Citation
APA
Chicago
ICMJE
MLA
NLM
Pizzo, S. V., Murray, J. C., & Gonias, S. L. (1986). Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator. Arch Pathol Lab Med, 110(6), 517–519.
Pizzo, S. V., J. C. Murray, and S. L. Gonias. “Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.” Arch Pathol Lab Med 110, no. 6 (June 1986): 517–19.
Pizzo SV, Murray JC, Gonias SL. Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator. Arch Pathol Lab Med. 1986 Jun;110(6):517–9.
Pizzo, S. V., et al. “Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.” Arch Pathol Lab Med, vol. 110, no. 6, June 1986, pp. 517–19.
Pizzo SV, Murray JC, Gonias SL. Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator. Arch Pathol Lab Med. 1986 Jun;110(6):517–519.
Published In
Arch Pathol Lab Med
ISSN
0003-9985
Publication Date
June 1986
Volume
110
Issue
6
Start / End Page
517 / 519
Location
United States
Related Subject Headings
- Vasculitis
- Tissue Plasminogen Activator
- Skin Diseases
- Skin
- Pathology
- Male
- Humans
- Fibrinolysis
- Female
- Atrophy