Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.

Journal Article (Journal Article)

Atrophie blanche is a skin disorder characterized by recurrent ulceration and fibrosis. It is one of a group of cutaneous vasculitides associated with decreased blood fibrinolytic activity. We examined pre- and post-venous occlusion plasma from eight patients with atrophie blanche for release of vascular (tissue-type) plasminogen activator (t-PA). The average plasma level of releasable t-PA was only 0.03 IU/mL, compared with 0.70 IU/mL for 118 healthy controls. Therefore, the fibrinolytic disorder in atrophie blanche is associated with defective release of t-PA from blood vessel walls.

Full Text

Duke Authors

Cited Authors

  • Pizzo, SV; Murray, JC; Gonias, SL

Published Date

  • June 1986

Published In

Volume / Issue

  • 110 / 6

Start / End Page

  • 517 - 519

PubMed ID

  • 3085632

International Standard Serial Number (ISSN)

  • 0003-9985


  • eng

Conference Location

  • United States