Immunohistochemical studies of cell differentiation in a juxtaglomerular tumor.

Journal Article (Journal Article)

A renal tumor removed from a 29-year-old woman, who recently had had onset of primary hypertension, showed the histologic and ultrastructural features of a renin-secretory juxtaglomerular cell tumor. The expression of Factor VIII-related antigen (FVIII-RAG) was evaluated to identify endothelial differentiation of tumor cells in this lesion. Control tissue and vessels within the tumor showed normal expression of FVIII-RAG, but tumor cells as well as normal juxtaglomerular cells showed no localization of this antigen, which suggests the nonendothelial nature of these specialized cells.

Full Text

Duke Authors

Cited Authors

  • Sanfilippo, F; Pizzo, SV; Croker, BP

Published Date

  • November 1, 1982

Published In

Volume / Issue

  • 106 / 12

Start / End Page

  • 604 - 607

PubMed ID

  • 6814398

International Standard Serial Number (ISSN)

  • 0003-9985


  • eng

Conference Location

  • United States