Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.

Journal Article

A family is described in which venous thrombosis developed in five members as early as 14 years of age. Routine coagulation studies, plasma antithrombin III, factor V, plasminogen, beta-thromboglobulin, fibrinopeptide A, prothrombin fragment F1+2, and thrombin-antithrombin III complex were all within normal limits. However, defective release of vascular plasminogen activator was observed on several occasions in all five subjects as compared with a control population of 125 persons (0.04 Committee on Thrombolytic Agents [CTA] units/ml plasma as compared with 0.21 CTS units/ml). In addition, levels of factor VII/von Willebrand's factor were significantly elevated above the normal range in this pedigree.

Full Text

Duke Authors

Cited Authors

  • Stead, NW; Bauer, KA; Kinney, TR; Lewis, JG; Campbell, EE; Shifman, MA; Rosenberg, RD; Pizzo, SV

Published Date

  • January 1, 1983

Published In

Volume / Issue

  • 74 / 1

Start / End Page

  • 33 - 39

PubMed ID

  • 6401391

International Standard Serial Number (ISSN)

  • 0002-9343

Language

  • eng

Conference Location

  • United States