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Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.

Publication ,  Journal Article
Stead, NW; Bauer, KA; Kinney, TR; Lewis, JG; Campbell, EE; Shifman, MA; Rosenberg, RD; Pizzo, SV
Published in: Am J Med
January 1983

A family is described in which venous thrombosis developed in five members as early as 14 years of age. Routine coagulation studies, plasma antithrombin III, factor V, plasminogen, beta-thromboglobulin, fibrinopeptide A, prothrombin fragment F1+2, and thrombin-antithrombin III complex were all within normal limits. However, defective release of vascular plasminogen activator was observed on several occasions in all five subjects as compared with a control population of 125 persons (0.04 Committee on Thrombolytic Agents [CTA] units/ml plasma as compared with 0.21 CTS units/ml). In addition, levels of factor VII/von Willebrand's factor were significantly elevated above the normal range in this pedigree.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

January 1983

Volume

74

Issue

1

Start / End Page

33 / 39

Location

United States

Related Subject Headings

  • von Willebrand Factor
  • Thrombophlebitis
  • Thrombin
  • Platelet Aggregation
  • Plasminogen Activators
  • Plasminogen
  • Pedigree
  • Male
  • Humans
  • General & Internal Medicine
 

Citation

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MLA
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Stead, N. W., Bauer, K. A., Kinney, T. R., Lewis, J. G., Campbell, E. E., Shifman, M. A., … Pizzo, S. V. (1983). Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor. Am J Med, 74(1), 33–39. https://doi.org/10.1016/0002-9343(83)91115-4
Stead, N. W., K. A. Bauer, T. R. Kinney, J. G. Lewis, E. E. Campbell, M. A. Shifman, R. D. Rosenberg, and S. V. Pizzo. “Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.Am J Med 74, no. 1 (January 1983): 33–39. https://doi.org/10.1016/0002-9343(83)91115-4.
Stead NW, Bauer KA, Kinney TR, Lewis JG, Campbell EE, Shifman MA, et al. Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor. Am J Med. 1983 Jan;74(1):33–9.
Stead, N. W., et al. “Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.Am J Med, vol. 74, no. 1, Jan. 1983, pp. 33–39. Pubmed, doi:10.1016/0002-9343(83)91115-4.
Stead NW, Bauer KA, Kinney TR, Lewis JG, Campbell EE, Shifman MA, Rosenberg RD, Pizzo SV. Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor. Am J Med. 1983 Jan;74(1):33–39.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

January 1983

Volume

74

Issue

1

Start / End Page

33 / 39

Location

United States

Related Subject Headings

  • von Willebrand Factor
  • Thrombophlebitis
  • Thrombin
  • Platelet Aggregation
  • Plasminogen Activators
  • Plasminogen
  • Pedigree
  • Male
  • Humans
  • General & Internal Medicine