Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies.


Journal Article

Vascular plasminogen activator levels were measured preoperatively in 66 women with gynecologic malignancies. These levels were compared to levels in a matched control group of 84 women and to the incidence of postoperative venous thromboembolic disease in the patient group. Significantly lower levels of plasminogen activator were measured in patients who developed thrombotic complications (p = 0.0014). When results were stratified according to tumor location, patients with ovarian carcinoma had significantly higher activator levels than those found in control subjects (p = 0.0072), and significantly lower levels were associated with endometrial malignancy (p = 0.0140). Measurement of releasable plasminogen activator before operation may be an effective, noninvasive means of identifying patients potentially at risk for venous thromboembolic disease. Postoperative measurement of plasminogen activator may eventually find a role in monitoring tumor therapy and recurrence.

Full Text

Duke Authors

Cited Authors

  • Gore, M; Miller, KE; Soong, SJ; Clarke-Pearson, DL; Pizzo, SV

Published Date

  • August 15, 1984

Published In

Volume / Issue

  • 149 / 8

Start / End Page

  • 830 - 834

PubMed ID

  • 6540521

Pubmed Central ID

  • 6540521

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/0002-9378(84)90599-4


  • eng

Conference Location

  • United States