Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen.
Publication
, Journal Article
Edelberg, JM; Gonzalez-Gronow, M; Pizzo, SV
Published in: Biochemistry
March 21, 1989
Lipoprotein a [Lp(a)] inhibits human plasminogen (Pg) conversion to plasmin (Pm) by streptokinase- (SK-) mediated activation. Kinetic and binding studies indicate that Lp(a) inhibits Pg activation by competitive and uncompetitive inhibition. Lp(a) competes with Pg for SK and forms a stable complex. Lp(a) does not, however, inhibit Pg activation by the proteolytic SK-Pm complex. The SK-Pg and SK-Pg(act) intermediate complexes are possible targets of the Lp(a) uncompetitive inhibition. The competitive inhibition constant (Kic) is 45 nM or 14 mg/dL, and the uncompetitive inhibition constant (Kiu) is 140 nM or 42 mg/dL, corresponding to physiologic and pathophysiologic Lp(a) concentrations, respectively.
Duke Scholars
Published In
Biochemistry
DOI
ISSN
0006-2960
Publication Date
March 21, 1989
Volume
28
Issue
6
Start / End Page
2370 / 2374
Location
United States
Related Subject Headings
- Streptokinase
- Protein Binding
- Plasminogen Activators
- Plasminogen
- Lipoproteins
- Lipoprotein(a)
- Kinetics
- Humans
- Chromatography, Gel
- Biochemistry & Molecular Biology
Citation
APA
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ICMJE
MLA
NLM
Edelberg, J. M., Gonzalez-Gronow, M., & Pizzo, S. V. (1989). Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen. Biochemistry, 28(6), 2370–2374. https://doi.org/10.1021/bi00432a004
Edelberg, J. M., M. Gonzalez-Gronow, and S. V. Pizzo. “Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen.” Biochemistry 28, no. 6 (March 21, 1989): 2370–74. https://doi.org/10.1021/bi00432a004.
Edelberg JM, Gonzalez-Gronow M, Pizzo SV. Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen. Biochemistry. 1989 Mar 21;28(6):2370–4.
Edelberg, J. M., et al. “Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen.” Biochemistry, vol. 28, no. 6, Mar. 1989, pp. 2370–74. Pubmed, doi:10.1021/bi00432a004.
Edelberg JM, Gonzalez-Gronow M, Pizzo SV. Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen. Biochemistry. 1989 Mar 21;28(6):2370–2374.
Published In
Biochemistry
DOI
ISSN
0006-2960
Publication Date
March 21, 1989
Volume
28
Issue
6
Start / End Page
2370 / 2374
Location
United States
Related Subject Headings
- Streptokinase
- Protein Binding
- Plasminogen Activators
- Plasminogen
- Lipoproteins
- Lipoprotein(a)
- Kinetics
- Humans
- Chromatography, Gel
- Biochemistry & Molecular Biology