Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen.


Journal Article

Lipoprotein a [Lp(a)] inhibits human plasminogen (Pg) conversion to plasmin (Pm) by streptokinase- (SK-) mediated activation. Kinetic and binding studies indicate that Lp(a) inhibits Pg activation by competitive and uncompetitive inhibition. Lp(a) competes with Pg for SK and forms a stable complex. Lp(a) does not, however, inhibit Pg activation by the proteolytic SK-Pm complex. The SK-Pg and SK-Pg(act) intermediate complexes are possible targets of the Lp(a) uncompetitive inhibition. The competitive inhibition constant (Kic) is 45 nM or 14 mg/dL, and the uncompetitive inhibition constant (Kiu) is 140 nM or 42 mg/dL, corresponding to physiologic and pathophysiologic Lp(a) concentrations, respectively.

Full Text

Duke Authors

Cited Authors

  • Edelberg, JM; Gonzalez-Gronow, M; Pizzo, SV

Published Date

  • March 21, 1989

Published In

Volume / Issue

  • 28 / 6

Start / End Page

  • 2370 - 2374

PubMed ID

  • 2525048

Pubmed Central ID

  • 2525048

International Standard Serial Number (ISSN)

  • 0006-2960

Digital Object Identifier (DOI)

  • 10.1021/bi00432a004


  • eng

Conference Location

  • United States