In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.

Published

Journal Article

We examined the effect of acetaminophen and the structural analogues 2,6-dimethylacetaminophen, 3,5-dimethylacetaminophen, and N-acetyl-p-benzoquinone imine on human platelet aggregation, 14C-serotonin secretion, and thromboxane B2 synthesis. Preincubation with 1 mM acetaminophen for 2 min completely inhibited arachidonic acid- and collagen-stimulated platelet aggregation. Thromboxane B2 production and 14C-serotonin secretion by arachidonic acid-stimulated platelets also were completely inhibited. Preincubation of platelets with 1 mM 3,5-dimethylacetaminophen inhibited collagen and arachidonic acid-induced aggregation and arachidonic acid-stimulated thromboxane B2 synthesis, while treatment with 2,6-dimethylacetaminophen did not inhibit aggregation and blocked thromboxane B2 formation to a much lesser degree. Preincubation with 1 mM N-acetyl-p-benzoquinone imine inhibited arachidonic acid-induced aggregation and 14C-serotonin secretion but had no effect on arachidonic acid-induced thromboxane B2 formation and collagen-induced platelet aggregation.

Full Text

Duke Authors

Cited Authors

  • Shorr, RI; Kao, KJ; Pizzo, SV; Rauckman, EJ; Rosen, GM

Published Date

  • April 1, 1985

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • 33 - 43

PubMed ID

  • 3923647

Pubmed Central ID

  • 3923647

International Standard Serial Number (ISSN)

  • 0049-3848

Digital Object Identifier (DOI)

  • 10.1016/0049-3848(85)90005-2

Language

  • eng

Conference Location

  • United States