Skip to main content
Journal cover image

Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.

Publication ,  Journal Article
Pizzo, SV
Published in: Am J Med
September 11, 1989

Antithrombin III (ATIII) clearance from blood occurs by redistribution into the extravascular compartment and by binding to the endothelial surface. When, however, ATIII reacts with a proteinase such as alpha-thrombin, the complex is rapidly cleared from the circulation (half-life is approximately five minutes) by a receptor present on hepatocytes. This receptor binds a number of other serine proteinase inhibitors that are members of the class designated as the "serpins." ATIII, alpha 1-proteinase inhibitor, heparin cofactor II, and alpha 1-antichymotrypsin proteinase complexes bind to the same hepatic receptor, now designated as serpin receptor 1. Proteinase complexes with alpha 2-antiplasmin, another member of the serpin class, do not bind to serpin receptor 1. Recent studies suggest that the specificity of the receptor for serpins may reside in the so-called D helix (nomenclature based on the structure of alpha 1-proteinase inhibitor). The presence of ATIII on the surface of endothelial cells offers a unique mechanism for regulating proteinases formed during coagulation. Since this ATIII is probably associated with heparin-like substances and exists in a high-affinity state, the inhibitor rapidly binds proteinases such as alpha-thrombin. Once the complex forms, its affinity for heparinoids is decreased compared with ATIII, allowing the complex to dissociate from the endothelial surface for rapid clearance by the liver.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

September 11, 1989

Volume

87

Issue

3B

Start / End Page

10S / 14S

Location

United States

Related Subject Headings

  • Serpins
  • Receptors, Cell Surface
  • Rabbits
  • Peptide Hydrolases
  • Mice
  • Liver
  • Humans
  • General & Internal Medicine
  • Binding Sites
  • Antithrombin III
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pizzo, S. V. (1989). Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes. Am J Med, 87(3B), 10S-14S. https://doi.org/10.1016/0002-9343(89)80524-8
Pizzo, S. V. “Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.Am J Med 87, no. 3B (September 11, 1989): 10S-14S. https://doi.org/10.1016/0002-9343(89)80524-8.
Pizzo, S. V. “Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.Am J Med, vol. 87, no. 3B, Sept. 1989, pp. 10S-14S. Pubmed, doi:10.1016/0002-9343(89)80524-8.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

September 11, 1989

Volume

87

Issue

3B

Start / End Page

10S / 14S

Location

United States

Related Subject Headings

  • Serpins
  • Receptors, Cell Surface
  • Rabbits
  • Peptide Hydrolases
  • Mice
  • Liver
  • Humans
  • General & Internal Medicine
  • Binding Sites
  • Antithrombin III