A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin.
Publication
, Journal Article
Feldman, SR; Pizzo, SV
Published in: Semin Thromb Hemost
July 1986
alpha 2-Macroglobulin inhibits many proteinases by a unique mechanism termed "trapping" depicted in Figure 3A,B. This article details a mechanism by which a large proteinase, such as plasmin, binds in a molar ratio between 1 and 2 to 1 proteinase to inhibitor. The article also discusses the placement of the bait region in relation to the thiol-esters within this model. Future investigation is required to confirm the hypothesized mechanism of plasmin binding as well as the hypothesized location of the bait region.
Duke Scholars
Published In
Semin Thromb Hemost
DOI
ISSN
0094-6176
Publication Date
July 1986
Volume
12
Issue
3
Start / End Page
223 / 225
Location
United States
Related Subject Headings
- alpha-Macroglobulins
- Protein Conformation
- Protease Inhibitors
- Models, Molecular
- Cardiovascular System & Hematology
- Binding Sites
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Feldman, S. R., & Pizzo, S. V. (1986). A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin. Semin Thromb Hemost, 12(3), 223–225. https://doi.org/10.1055/s-2007-1003556
Feldman, S. R., and S. V. Pizzo. “A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin.” Semin Thromb Hemost 12, no. 3 (July 1986): 223–25. https://doi.org/10.1055/s-2007-1003556.
Feldman SR, Pizzo SV. A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin. Semin Thromb Hemost. 1986 Jul;12(3):223–5.
Feldman, S. R., and S. V. Pizzo. “A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin.” Semin Thromb Hemost, vol. 12, no. 3, July 1986, pp. 223–25. Pubmed, doi:10.1055/s-2007-1003556.
Feldman SR, Pizzo SV. A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin. Semin Thromb Hemost. 1986 Jul;12(3):223–225.
Published In
Semin Thromb Hemost
DOI
ISSN
0094-6176
Publication Date
July 1986
Volume
12
Issue
3
Start / End Page
223 / 225
Location
United States
Related Subject Headings
- alpha-Macroglobulins
- Protein Conformation
- Protease Inhibitors
- Models, Molecular
- Cardiovascular System & Hematology
- Binding Sites
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences