A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin.

Journal Article (Journal Article)

alpha 2-Macroglobulin inhibits many proteinases by a unique mechanism termed "trapping" depicted in Figure 3A,B. This article details a mechanism by which a large proteinase, such as plasmin, binds in a molar ratio between 1 and 2 to 1 proteinase to inhibitor. The article also discusses the placement of the bait region in relation to the thiol-esters within this model. Future investigation is required to confirm the hypothesized mechanism of plasmin binding as well as the hypothesized location of the bait region.

Full Text

Duke Authors

Cited Authors

  • Feldman, SR; Pizzo, SV

Published Date

  • July 1986

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 223 - 225

PubMed ID

  • 2430335

International Standard Serial Number (ISSN)

  • 0094-6176

Digital Object Identifier (DOI)

  • 10.1055/s-2007-1003556


  • eng

Conference Location

  • United States