Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor.

Journal Article (Journal Article)

Site-directed mutagenesis of residues in the receptor binding fragment of rat alpha 1-macroglobulin identify residues 1377 and 1378 (human numbering) as crucial for interaction with the alpha 2M signaling receptor on murine macrophages. Secondary structure prediction and signaling studies with the mutant proteins suggest the alpha 2M signaling receptor binding site involves part of a loop-helix-loop motif comprised of residues 1372-1378.

Full Text

Duke Authors

Cited Authors

  • Howard, GC; DeCamp, DL; Misra, UK; Pizzo, SV

Published Date

  • October 17, 1996

Published In

Volume / Issue

  • 1297 / 2

Start / End Page

  • 111 - 114

PubMed ID

  • 8917609

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/s0167-4838(96)00135-5

Language

  • eng

Conference Location

  • Netherlands