Increased releasable vascular plasminogen activator and a bleeding diathesis.

Journal Article (Journal Article)

A 66-year-old man with metastatic prostatic carcinoma treated with high-dose (5 mg) diethylstilbestrol therapy underwent orchiectomy to allow discontinuation of estrogen. An extensive ecchymosis developed postoperatively in an area covered by elastic dressing tape; subsequently, it was learned that the patient had a recent history of frequent ecchymoses with mild trauma that proceeded to vesiculation. His alpha2-antiplasmin level was 132 percent, fibrin split products 4 micrograms/ml, and fibrinogen 293 mg/dl; routine coagulation results were normal. However, the level of releasable vascular plasminogen activator in a specimen drawn prior to surgery was 3.6 CTA units/ml, the highest value ever reported in this laboratory.

Full Text

Duke Authors

Cited Authors

  • Walther, PJ; Gore, M; Pizzo, SV

Published Date

  • September 1, 1984

Published In

Volume / Issue

  • 77 / 3

Start / End Page

  • 566 - 568

PubMed ID

  • 6540987

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(84)90123-2


  • eng

Conference Location

  • United States