Characterization of murine peritoneal macrophage receptors for fibrin(ogen) degradation products.

Journal Article

The binding of human fibrinogen degradation fragments D1, E, X, and Y, as well as fibrin fragment D1 dimer, to mouse peritoneal macrophages was examined. A Scatchard plot of fragment D1 binding was biphasic, suggesting two classes of receptors. Fragments D1, D1 dimer, X, and Y in low concentrations bound to macrophages with high affinity (Kd = 23 to 73 X 10(-11) mol/L). Fragment E bound specifically but at a much lower level than the other fragments. Fragment D1 was able to compete for the binding of radiolabeled fragments X and Y but not radiolabeled fragment E. These studies indicate that fragments D and E are recognized by separate receptor systems but that all of the fibrinogen degradation products that contain the D domain are recognized by the same receptor system.

Full Text

Duke Authors

Cited Authors

  • Rajagopalan, S; Pizzo, SV

Published Date

  • May 1, 1986

Published In

Volume / Issue

  • 67 / 5

Start / End Page

  • 1224 - 1228

PubMed ID

  • 3008885

International Standard Serial Number (ISSN)

  • 0006-4971

Language

  • eng

Conference Location

  • United States