B cells in epithelial and perivascular compartments of human adult thymus.

Published

Journal Article

The thymus is the site of T-cell differentiation. However, the relatively recent observation that B cells are also present in the human thymus has prompted studies to determine the origin and function of these B cells. Our studies show that phenotypically distinguishable B cell populations are located within both the thymic medulla and the thymic perivascular space and that cellular trafficking occurs between these compartments, including B cells trafficking from the periphery. The numbers of thymic B cells increase with age, correlating with increases in lymphocyte-rich regions of thymic perivascular space that are prominent between ages 10 and 50 years. B cells within both thymic epithelial and perivascular compartments contain mutated immunoglobulin VH sequences characteristic of post-germinal center B cells, suggesting that the B cells that most often give rise to thymic B-cell lymphomas may originate from either the thymic medulla or perivascular space.

Full Text

Duke Authors

Cited Authors

  • Flores, KG; Li, J; Hale, LP

Published Date

  • September 2001

Published In

Volume / Issue

  • 32 / 9

Start / End Page

  • 926 - 934

PubMed ID

  • 11567221

Pubmed Central ID

  • 11567221

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1053/hupa.2001.27106

Language

  • eng

Conference Location

  • United States