Skip to main content
Journal cover image

B cells in epithelial and perivascular compartments of human adult thymus.

Publication ,  Journal Article
Flores, KG; Li, J; Hale, LP
Published in: Hum Pathol
September 2001

The thymus is the site of T-cell differentiation. However, the relatively recent observation that B cells are also present in the human thymus has prompted studies to determine the origin and function of these B cells. Our studies show that phenotypically distinguishable B cell populations are located within both the thymic medulla and the thymic perivascular space and that cellular trafficking occurs between these compartments, including B cells trafficking from the periphery. The numbers of thymic B cells increase with age, correlating with increases in lymphocyte-rich regions of thymic perivascular space that are prominent between ages 10 and 50 years. B cells within both thymic epithelial and perivascular compartments contain mutated immunoglobulin VH sequences characteristic of post-germinal center B cells, suggesting that the B cells that most often give rise to thymic B-cell lymphomas may originate from either the thymic medulla or perivascular space.

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

September 2001

Volume

32

Issue

9

Start / End Page

926 / 934

Location

United States

Related Subject Headings

  • Thymus Neoplasms
  • Thymus Gland
  • Polymerase Chain Reaction
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, B-Cell
  • Infant, Newborn
  • Infant
  • Immunoglobulin Variable Region
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Flores, K. G., Li, J., & Hale, L. P. (2001). B cells in epithelial and perivascular compartments of human adult thymus. Hum Pathol, 32(9), 926–934. https://doi.org/10.1053/hupa.2001.27106
Flores, K. G., J. Li, and L. P. Hale. “B cells in epithelial and perivascular compartments of human adult thymus.Hum Pathol 32, no. 9 (September 2001): 926–34. https://doi.org/10.1053/hupa.2001.27106.
Flores KG, Li J, Hale LP. B cells in epithelial and perivascular compartments of human adult thymus. Hum Pathol. 2001 Sep;32(9):926–34.
Flores, K. G., et al. “B cells in epithelial and perivascular compartments of human adult thymus.Hum Pathol, vol. 32, no. 9, Sept. 2001, pp. 926–34. Pubmed, doi:10.1053/hupa.2001.27106.
Flores KG, Li J, Hale LP. B cells in epithelial and perivascular compartments of human adult thymus. Hum Pathol. 2001 Sep;32(9):926–934.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

September 2001

Volume

32

Issue

9

Start / End Page

926 / 934

Location

United States

Related Subject Headings

  • Thymus Neoplasms
  • Thymus Gland
  • Polymerase Chain Reaction
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, B-Cell
  • Infant, Newborn
  • Infant
  • Immunoglobulin Variable Region