Age-related thymic atrophy in the guinea pig.


Journal Article

We have characterized age-related thymic atrophy in the guinea pig, including identification of antibodies that allow immunohistochemical assessment of thymopoiesis. Age-related thymic atrophy in guinea pigs more closely resembles what occurs in humans histologically and in thymus weight, cellularity, and percent functional area than do other rodent models. The guinea pig model is thus particularly well-suited to study the role of the thymic perivascular space in age-related thymic atrophy. We next tested the hypothesis that dietary supplementation with Vitamin C could prevent or delay age-related thymic atrophy. Thymus histology, weight, cellularity, and percent functional area did not differ at 12 months between groups that received 3, 30, or 150 mg Vitamin C daily from 4 months of age. Thus long-term supplementation with up to 130 mg/kg/day Vitamin C is insufficient to influence the time course and extent of age-related thymic atrophy in guinea pigs.

Full Text

Duke Authors

Cited Authors

  • Hale, LP; Clark, AG; Li, J; Greer, PK; Byers Kraus, V

Published Date

  • June 2001

Published In

Volume / Issue

  • 25 / 5-6

Start / End Page

  • 509 - 518

PubMed ID

  • 11356230

Pubmed Central ID

  • 11356230

International Standard Serial Number (ISSN)

  • 0145-305X

Digital Object Identifier (DOI)

  • 10.1016/s0145-305x(00)00071-9


  • eng

Conference Location

  • United States