Infantile sialic acid storage disease: a rare cause of cytoplasmic vacuolation in pediatric patients.

Journal Article (Journal Article;Review)

We report a case of infantile sialic acid storage disease (ISSD) in a black infant presenting in utero with nonimmune hydrops, ascites, and anemia requiring intrauterine transfusion. Upon birth, the patient had prominent edema, large anterior fontanelle, partial absence of the rectus abdominis, clubbing of the left foot, gingival hypertrophy, short first metatarsals, prominent scrotal raphe, right heart dilatation, and left ventricular dysfunction. Radiographs showed pulmonary hypoplasia and epiphyseal stippling. He died of respiratory failure at day 2. Autopsy demonstrated capillary hemangiomata, remote cerebral hemorrhages, and central nervous system periventricular leukomalacia, as well as severe cardio- and hepatosplenomegaly. Multiple single membrane-limited vacuoles consistent with enlarged lysosomes were present in virtually all cell types examined, with striking involvement of liver, myocardium, and placenta. Vacuolar contents were not identifiable by electron microscopy. Demonstration of elevated free sialic acid in urine, amniotic fluid, and cultured fibroblasts confirmed the diagnosis of ISSD. Characteristics of sialic acid storage diseases and their diagnosis are reviewed. ISSD should be considered in infants with empty cytoplasmic vacuoles in multiple tissue types.

Full Text

Duke Authors

Cited Authors

  • Hale, LP; van de Ven, CJ; Wenger, DA; Bradford, WD; Kahler, SG

Published Date

  • May 1995

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 443 - 453

PubMed ID

  • 8597831

International Standard Serial Number (ISSN)

  • 1077-1042

Digital Object Identifier (DOI)

  • 10.3109/15513819509026980


  • eng

Conference Location

  • United States