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Pharmacological approach to functional reorganization: the role of norepinephrine.

Publication ,  Journal Article
Goldstein, LB
Published in: Rev Neurol (Paris)
1999

Pharmacological studies in laboratory animals show that systemically administered drugs that modulate the levels of specific central neurotransmitters can influence post brain injury behavioral recovery. Several lines of evidence support an important role of central norepinephrine. Selective lesions of central noradrenergic pathways impair recovery after a subsequent injury to the cerebral cortex. Drugs that deplete central norepinephrine, block alpha 1-adrenergic receptors, or decrease norepinephrine release (alpha 2-adrenergic receptor agonists) impede recovery whereas drugs that increase norepinephrine release (alpha 2-adrenergic receptor antagonists) or sympathomimetics (amphetamine) facilitate recovery. These studies also provide insights into the potential neurobiological processes underlying these drug effects.

Duke Scholars

Published In

Rev Neurol (Paris)

ISSN

0035-3787

Publication Date

1999

Volume

155

Issue

9

Start / End Page

731 / 736

Location

France

Related Subject Headings

  • Time Factors
  • Sympathomimetics
  • Norepinephrine
  • Neurotransmitter Agents
  • Neurology & Neurosurgery
  • Humans
  • Brain Injury, Chronic
  • Animals
  • Amphetamine
  • Adrenergic alpha-Antagonists
 

Citation

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MLA
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Goldstein, L. B. (1999). Pharmacological approach to functional reorganization: the role of norepinephrine. Rev Neurol (Paris), 155(9), 731–736.
Goldstein, L. B. “Pharmacological approach to functional reorganization: the role of norepinephrine.Rev Neurol (Paris) 155, no. 9 (1999): 731–36.
Goldstein LB. Pharmacological approach to functional reorganization: the role of norepinephrine. Rev Neurol (Paris). 1999;155(9):731–6.
Goldstein, L. B. “Pharmacological approach to functional reorganization: the role of norepinephrine.Rev Neurol (Paris), vol. 155, no. 9, 1999, pp. 731–36.
Goldstein LB. Pharmacological approach to functional reorganization: the role of norepinephrine. Rev Neurol (Paris). 1999;155(9):731–736.
Journal cover image

Published In

Rev Neurol (Paris)

ISSN

0035-3787

Publication Date

1999

Volume

155

Issue

9

Start / End Page

731 / 736

Location

France

Related Subject Headings

  • Time Factors
  • Sympathomimetics
  • Norepinephrine
  • Neurotransmitter Agents
  • Neurology & Neurosurgery
  • Humans
  • Brain Injury, Chronic
  • Animals
  • Amphetamine
  • Adrenergic alpha-Antagonists