Large-dose infusions of heparinoid ORG 10172 in ischemic stroke.

Journal Article

We evaluated the safety and possible efficacy of large doses of the heparinoid ORG 10172 in 57 patients with acute or progressing ischemic stroke. Patients received a loading bolus of the drug followed by a maintenance intravenous infusion for 7 days. The plasma level of ORG 10172 was monitored by the degree of inhibition of coagulation factor Xa. In general, the drug was well tolerated and few hemorrhagic complications occurred. Two patients with large cardioembolic hemispheric strokes had intracranial hemorrhagic complications. Most patients improved during treatment. By 3 months after the stroke, 37 patients (65%) had a favorable outcome (minimal or no residual disability). This study suggests that high-dose intravenous infusions of ORG 10172 can be safely given to patients with acute ischemic stroke.

Full Text

Duke Authors

Cited Authors

  • Massey, EW; Biller, J; Davis, JN; Adams, HP; Marler, JR; Goldstein, LB; Alberts, M; Bruno, A

Published Date

  • September 1990

Published In

Volume / Issue

  • 21 / 9

Start / End Page

  • 1289 - 1292

PubMed ID

  • 2396265

Pubmed Central ID

  • 2396265

International Standard Serial Number (ISSN)

  • 0039-2499

Digital Object Identifier (DOI)

  • 10.1161/01.str.21.9.1289


  • eng

Conference Location

  • United States