Skip to main content
Journal cover image

Rapid reliable measurement of lesion parameters for studies of motor recovery after sensorimotor cortex injury in the rat.

Publication ,  Journal Article
Goldstein, LB
Published in: J Neurosci Methods
June 1993

Measurement of the ability of rats to traverse a narrow elevated beam has been used to quantitate motor recovery after unilateral injury to the sensorimotor cortex. Lesion extent is an important variable to consider in studies of the effects of drugs on beam-walking recovery. However, traditional histologic evaluation precludes neurochemical measurements in brain tissue. The present study was carried out to determine how well the dimensions of the lesion measured at the surface of the brain correlate with subsequent motor recovery in comparison with standard histology. The maximum medial extent of the lesion (closest approximation of the lesion to the inter-hemispheric fissure) was correlated with subsequent recovery (Spearman r = 0.61, P = 0.02) whereas the lesion surface area was not correlated with recovery (Spearman r = 0.25, P = 0.30). This data compared favorably with measures that were dependent on histologic tissue preparation. Furthermore, measurements of surface lesion parameters were highly reliable (intra- and inter-observer reliability for lesion surface maximum medial extent and lesion surface area were r2 = 0.88, 0.96, 0.97, and 0.96, P = 0.0001, respectively). Lesion surface parameters provide a valid and reliable measure of lesion size and extent for studies of beam-walking recovery after injury to the sensorimotor cortex.

Duke Scholars

Published In

J Neurosci Methods

DOI

ISSN

0165-0270

Publication Date

June 1993

Volume

48

Issue

1-2

Start / End Page

35 / 42

Location

Netherlands

Related Subject Headings

  • Somatosensory Cortex
  • Rats, Sprague-Dawley
  • Rats
  • Postural Balance
  • Paraffin Embedding
  • Neurology & Neurosurgery
  • Motor Cortex
  • Male
  • Locomotion
  • Image Processing, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goldstein, L. B. (1993). Rapid reliable measurement of lesion parameters for studies of motor recovery after sensorimotor cortex injury in the rat. J Neurosci Methods, 48(1–2), 35–42. https://doi.org/10.1016/s0165-0270(05)80005-6
Goldstein, L. B. “Rapid reliable measurement of lesion parameters for studies of motor recovery after sensorimotor cortex injury in the rat.J Neurosci Methods 48, no. 1–2 (June 1993): 35–42. https://doi.org/10.1016/s0165-0270(05)80005-6.
Goldstein, L. B. “Rapid reliable measurement of lesion parameters for studies of motor recovery after sensorimotor cortex injury in the rat.J Neurosci Methods, vol. 48, no. 1–2, June 1993, pp. 35–42. Pubmed, doi:10.1016/s0165-0270(05)80005-6.
Journal cover image

Published In

J Neurosci Methods

DOI

ISSN

0165-0270

Publication Date

June 1993

Volume

48

Issue

1-2

Start / End Page

35 / 42

Location

Netherlands

Related Subject Headings

  • Somatosensory Cortex
  • Rats, Sprague-Dawley
  • Rats
  • Postural Balance
  • Paraffin Embedding
  • Neurology & Neurosurgery
  • Motor Cortex
  • Male
  • Locomotion
  • Image Processing, Computer-Assisted