Construction of low-variability litters of preweaning mice.

Journal Article (Journal Article)

Mouse litter variation at weaning stems from a combination of genetic makeup, intrauterine experience, and postnatal maternal care. The 1st 2 factors may be matched at birth by making up separate litters out of littermate pairs whose birth weights are equal (+/-.02 g). Maternal competence may be matched by exchanging the mothers between the 2 cages each day. These tactics yield litters at weaning whose variability has been very much reduced. The range of litter-average body weights has been reduced from about 40 percent to about 5 percent and the range of litter-average brain weights has been reduced from about 15 percent to about 1-2 percent.

Full Text

Duke Authors

Cited Authors

  • Epstein, HT; Goldstein, LB

Published Date

  • November 1977

Published In

Volume / Issue

  • 10 / 6

Start / End Page

  • 575 - 577

PubMed ID

  • 598624

Pubmed Central ID

  • 598624

International Standard Serial Number (ISSN)

  • 0012-1630

Digital Object Identifier (DOI)

  • 10.1002/dev.420100611


  • eng

Conference Location

  • United States