Neurotransmitters and motor activity: effects on functional recovery after brain injury.

Journal Article (Journal Article;Review)

There are complex relationships among behavioral experience, brain morphology, and functional recovery of an animal before and after brain injury. A large series of experimental studies have shown that exogenous manipulation of central neurotransmitter levels can directly affect plastic changes in the brain and can modulate the effects of experience and training. These complex relationships provide a formidable challenge for studies aimed at understanding neurotransmitter effects on the recovery process. Experiments delineating norepinephrine-modulated locomotor recovery after injury to the cerebral cortex illustrate the close relationships among neurotransmitter levels, brain plasticity, and behavioral recovery. Understanding the neurobiological processes underlying recovery, and how they might be manipulated, may lead to novel strategies for improving recovery from stroke-related gait impairment in humans.

Full Text

Duke Authors

Cited Authors

  • Goldstein, LB

Published Date

  • October 2006

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 451 - 457

PubMed ID

  • 17012058

Pubmed Central ID

  • PMC3593407

International Standard Serial Number (ISSN)

  • 1545-5343

Digital Object Identifier (DOI)

  • 10.1016/j.nurx.2006.07.010


  • eng

Conference Location

  • United States